β‑asarone modulates Beclin‑1, LC3 and p62 expression to attenuate

p62 app  Reduction of p62 protein levels or interference with p62 function significantly increased cell death that was induced by the expression of mutant huntingtin We p62Sqstm1 is a key molecule for the selective autophagy To investigate how to induce p62 in cells, we performed a drug screening that activated or

Collectively, our data suggest that the downregulation of SEPTIN5 increases the autophagy-mediated degradation of APP CTFs, leading to reduced levels of Aβ in Molecular Psychiatry 2016 TLDR It is shown that increasing brain p62 expression rescues cognitive deficits in APPPS1 mice, a widely used animal model of AD

These results suggest that p62 may bind with C60 to form aggregates and induce autophagy in autophagosomes  P62 is a versatile protein involved in the delicate balance between cell death and survival, which is fundamental for cell fate decision