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Autophagic clearance of protein aggregates requires the ubiquitin-binding receptors p62 and NBR1 The p62 protein, also known as sequestosome 1 , has a

p62 com It has been suggested that p62 acts as an adaptor by binding ubiquitinated protein aggregates and targeting them for degradation by autophagy, therefore p62 , a ubiquitous and multifunctional protein, can direct ubiquitinated proteins to the proteasome or the growing autophagosome p62 SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic

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